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Dr. James
Miranda
Courses | Education | Research | Links
Contact Information
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Title:
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Professor of Chemistry
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Office
Hours:
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Fall 2019
Monday/Friday 8:00-9:30 am
TSC
2015
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E-mail:
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miranda@csus.edu
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Office
Phone:
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(916) 278-6189
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Mailing
Address:
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Sacramento
State, Department of Chemistry
6000 J Street
Sacramento, CA 95819-6057
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Courses
- Chem 24 (Organic Chemistry Lecture I)
- Chem 124 (Organic Chemistry Lecture II)
- Chem 25 (Organic Chemistry Laboratory)
- Chem 125 (Advanced Organic Chemistry Laboratory)
- Chem 128 (Organic Synthesis)
- Chem 20 (Organic Chemistry Lecture—Brief Course)
- Chem 20L (Introductory Organic Chemistry Laboratory)
- Chem 220 (Spectrometric Identification of Compounds)
- Chem 250 (Selected Topics In Chemistry—Organometallic
Chemistry)
- Chem 4 (Chemical Calculations)
- Chem 6A
(Introduction to General Chemistry)
- Chem 106 (Chemical
Concepts)
- NSM 21 (First Year
Seminar)
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Complete Course Websites are available on
Canvas
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I am actively recruiting undergraduate and graduate
students who are interested in participating in research in the exciting
field of organic chemistry. Please contact me at
miranda@csus.edu. For more
information, see the Research section.
Education
Ph.D. Chemistry,
University of California Santa Barbara
M.S. Chemistry,
California State University Fresno
B.S. Biochemistry,
California
Polytechnic State University San Luis Obispo
Research
(Organic Chemistry)
- "Since their launch in 1901, the Nobel Prizes
have rewarded more achievements in the study of carbon-based substances,
otherwise known as organic chemistry, than in any other traditional
chemistry discipline."
Nobel
Prizes in Organic Chemistry
- Our research interest primarily lies in developing
new methodology for the organic synthesis of biologically active
molecules. Usually these complex molecules are not only important in
medicinal chemistry as therapeutic agents, but are also interesting from
a structural point of view. We also seek to understand the mechanism of
these important new reactions. A typical researcher in my group can
expect to gain experience in a great variety of organic chemistry
laboratory techniques as well as gain valuable experience in the common
spectroscopic methods available to the organic chemist (NMR, IR, GC/MS,
HPLC, cyclic voltammetry, etc...)
- We are conducting mechanistic investigations into the
use of catalytic nickel (II) salen in electroreductive cyclization
reactions. For more information please see:
Clendenin. B; Miranda. J.A. "Polymer
Supported Ni(salen) Catalysts and Ni(II)-salen zeolite Y as Catalysts for
Heterogeneous Electrohydrocyclization Reactions" Int. J.
Electrochem. Sci., 2019, (14), 7995 – 8013.
Polymer
Supported Ni(salen) Catalysts and Ni(II)-salen zeolite Y as Catalysts for
Heterogeneous Electrohydrocyclization Reactions
Yates,
J.M.; Fell, J.S.; Miranda,
J.A.; Gherman, B.F. "Metal-Salens As Catalysts In
Electroreductive Cyclization and Electrohydrocyclization: Computational and
Experimental Studies", J.
Electrochem. Soc. 2013,
160(7), G3080-G3090.
Miranda,
J.A.;
Wade, C.J.; Little, R.D. “Indirect Electroreductive Cyclization and
Electrohydrocyclization Using Catalytic Reduced Nickel (II) Salen”, J. Org. Chem., 2005, 70(20), 8017.
Catalytic ERC
- We are investigating polymer supported vanadium
complexes as potential catalysts for the epoxidation of organic
substrates. We are currently exploring the scope of this reaction and
working on optimizing the conditions of the reaction as well.
- We are currently working with the Gherman group here at
CSUS on using computational chemistry to predict the experimental
reduction potential of various metal-salen complexes. The predicted
reduction potentials can then be used to determine if the metal-salen
complex can participate in mediated electroreductive cyclization
reactions. Our contribution to this project is to synthesize a series of
metal-salen compounds with various metal centers (Ni, Co, Cu, etc...)
and various groups (electron-withdrawing or electron donating) on the
aromatic rings. For more information, please see:
Bateni,
S.B.; England, K.R.; Galatti, A.T.; Kaur, H.; Mendiola, V.A.; Mitchell, A.R.;
Vu, M.H.; Gherman, B.F.; Miranda,
J.A. Beilstein
J. Org. Chem. 2009,
5, No. 82
- Vinylcyclopropane radical cyclization-fragmentation.
We are exploring a novel route towards eight-membered rings, such as
those found in the anti-tumor compound paclitaxel (shown below). For
more information please see:
Miranda,
J.A.;
Little, R.D. "Investigation of Vinylcyclopropane Monoradical
Cyclization-Fragmentation as a Possible Route towards Eight-Membered
Rings" Heterocycles, 2006, 70, 169 - 175.
Links
Chemistry
Links
Last updated:
8/28/2019
All rights reserved.
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